Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles
- 14 May 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- Vol. 49 (18), 5939-5948
- https://doi.org/10.1039/d0dt00930j
Abstract
Metal-based anion receptors have several important applications in sensing, separation and transport of negatively charged species. Amongst these receptors, di-zinc(II) complexes are of particular interest for the recognition of oxoanions, in particular phosphate derivatives. Herein we report the synthesis of a dizinc(s) receptor and show that it has high affinity and selectivity for bisphosphonates such as alendronate and etidronate - which are used to treat a number of skeletal disorders as well as showing interesting anticancer properties. The binding mode of the di-zinc(II) receptor with alendronate and etidronate has been unambiguously established by single crystal X-ray crystallography. In addition, by modifying the backbone of the receptor, we show that the drug-loaded receptor can be attached onto gold nanoparticles as potential drug-delivery vehicles.Funding Information
- Consejo Nacional de Ciencia y Tecnología (298826)
- Engineering and Physical Sciences Research Council (EP/L016737/1)
This publication has 39 references indexed in Scilit:
- Recent advances in recognition, sensing and extraction of phosphates: 2015 onwardsCoordination Chemistry Reviews, 2019
- Anion transport and supramolecular medicinal chemistryChemical Society Reviews, 2017
- Applications of Supramolecular Anion RecognitionChemical Reviews, 2015
- Anion sensing by small molecules and molecular ensemblesChemical Society Reviews, 2014
- Anion recognition and sensing with Zn(ii)–dipicolylamine complexesChemical Society Reviews, 2012
- Supramolecular complexation for environmental controlChemical Society Reviews, 2012
- Calixarene and Resorcarene Based Receptors: From Structural and Thermodynamic Studies to the Synthesis of a New Mercury(II) Selective MaterialThe Journal of Physical Chemistry B, 2011
- Anion recognition by hydrogen bonding: urea-based receptorsChemical Society Reviews, 2010
- Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(ii)–Dpa complexesChemical Communications, 2008
- C3v Symmetric Receptors Show High Selectivity and High Affinity for PhosphateJournal of the American Chemical Society, 2003