The effect of inhibitors of renal transport on the small intestine.
Open Access
- 1 December 1966
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 45 (12), 1854-1858
- https://doi.org/10.1172/jci105489
Abstract
Nonelectrolyte transport were studied in everted hamster small intestinal sacs. Ethacrynic acid, a diuretic agent, significantly inhibited amino acid, glucose, and pyrimidine transport. Water and Na transport was impaired by both ethacrynic acid and chlorothiazide. Probenecid inhibited amino acid transport only. These observations provide further evidence of functional similarities between the kidney and the small intestine. The relationship of cardiorenal drugs to intestinal absorption was discussed.This publication has 18 references indexed in Scilit:
- THE CHARACTERIZATION OF NEW ENERGY DEPENDENT CATION TRANSPORT PROCESSES IN RED BLOOD CELLSAnnals of the New York Academy of Sciences, 1966
- THE PROXIMAL TUBULAR HANDLING OF AMINO ACIDS AND OTHER NINHYDRIN-POSITIVE SUBSTANCESCanadian Journal of Physiology and Pharmacology, 1966
- Lack of Correlation Between Natriuretic Activity and Inhibition of Renal Na-K-Activated ATPase.Experimental Biology and Medicine, 1965
- Cathartics and the Sodium PumpNature, 1965
- Effects of Ethacrynic Acid (a New Saluretic Agent) on Renal Diluting and Concentrating Mechanisms: Evidence for Site of Action in the Loop of Henle*JCI Insight, 1964
- Thiazide DiureticsAnnual Review of Medicine, 1964
- Effect of cardioactive steroids on the active transport of non-electrolytesBiochimica et Biophysica Acta, 1963
- THE METABOLIC DISORDER IN HARTNUP DISEASEQJM: An International Journal of Medicine, 1960
- Electron microscopy of the kidneyAmerican Journal Of Medicine, 1958
- The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surfaceThe Journal of Physiology, 1954