Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase from Brain

Abstract

Adenosine 3',5'-monophosphate at a concentration of 5 x 10^-7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain. The data provide the first direct evidence of a biochemical action of adenosine 3',5'-monophosphate in the brain.