A 7-Hydroxymethyl Sulfate Ester as an Active Metabolite of 7,12-Dimethylbenz[ a ]anthracene
- 22 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4531), 403-405
- https://doi.org/10.1126/science.6800033
Abstract
7-Hydroxymethyl-12-methylbenz[alpha]anthracene (7-HMBA), a carcinogenic major metabolite of 7,12-dimethylbenz[alpha]anthracene (DMBA) in liver, was transformed by liver cytosolic sulfotransferase to reactive 7-HMBA sulfate, which is mutagenic toward Salmonella typhimurium strain TA98. The mutagenicity of 7-HMBA in the presence of hepatic sulfotransferase was much higher than that of DMBA or 7-HMBA in the presence of hepatic monooxygenase.This publication has 16 references indexed in Scilit:
- Variation in route of microsomal activation of 7,12-dimethylbenz[a]anthracene with substrate concentrationCarcinogenesis: Integrative Cancer Research, 1980
- The induction of sister chromatid exchanges by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene and 3-methylcholanthreneCancer Letters, 1979
- Cell and microsome mediated binding of 7, 12-dimethylbenz(a)anthracene to DNA studied by fluorescence spectroscopyCancer Letters, 1978
- Fluorescence spectral studies on the metabolic activation of 3‐methylcholanthrene and 7,12‐dimethylbenz[a]anthracene in mouse skinFEBS Letters, 1977
- Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA bindingBiochemical and Biophysical Research Communications, 1977
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Structure and activity in chemical carcinogenesis. Comparison of the reactions of 7-bromomethylbenz[α]anthracene and 7-bromomethyl-12-methylbenz[α]anthracene with mouse skin deoxyribonucleic acid in vivoBiochemistry, 1973
- Structure and activity in chemical carcinogenesis. Comparison of the reactions of 7-bromomethylbenz[a]anthracene and 7-bromomethyl-12-methylbenz[a]anthracene with deoxyribonucleic acid in bitroBiochemistry, 1973
- Reaction of 7-bromomethylbenz[a]anthracene with nucleic acids, polynucleotides, and nucleosidesBiochemistry, 1971
- Reactivity in vivo of the Carcinogen N -Hydroxy-2-acetylaminofluorene: Increase by Sulfate IonScience, 1970