Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo.
- 1 November 1981
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 127 (5), 1754-1758
- https://doi.org/10.4049/jimmunol.127.5.1754
Abstract
Effector lymphoid cells that inhibit hematogenous tumor metastasis in normal unimmunized mice were studied. Mice pretreated with cyclophosphamide (Cy) exhibited a diminished ability to destroy circulating tumor cells, which, in turn, caused an increased incidence of experimental pulmonary metastasis. Adoptive transfer of spleen cells from unimmunized syngeneic donors abrogated the Cy-induced enhancement of metastasis formation. The effector cell active in these adoptive transfer experiments was sensitive to treatment with specific anti-NK-1.2 antibodies and complement. This treatment was shown by in vitro tests to deplete or inactivate NK cells selectively. These findings provide direct evidence that NK cells play a significant role in the inhibition of hematogenous tumor metastases in vivo.This publication has 15 references indexed in Scilit:
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