GONADOTROPHIN SUPPRESSION BY STEROIDS IN NORMAL, ADULT MALE RATS
- 1 April 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 84 (4), 842-849
- https://doi.org/10.1530/acta.0.0840842
Abstract
Effects of s.c. administration of various doses of different steroids on serum levels of LH [luteinizing hormone] and FSH [follicle stimulating hormone] in normal, adult male rats were investigated. Each steroid was injected daily during 7 days in doses of 50, 25, 12.5 or 6.25 .mu.g/100 g body wt. Ring A 5.alpha.-reduced testosterone metabolites exerted high activity in suppressing serum LH and FSH levels. 5.alpha.-Androstane-3.beta.,17.beta.-diol had in the doses tested had no such effects on serum gonadotropins. Serum LH concentrations in normal rats appeared more sensitive to steroid treatment than serum FSH concentrations.This publication has 4 references indexed in Scilit:
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