Evolving concepts in biofilm infections
Top Cited Papers
- 1 July 2009
- journal article
- review article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 11 (7), 1034-1043
- https://doi.org/10.1111/j.1462-5822.2009.01323.x
Abstract
Several pathogens associated with chronic infections, including Pseudomonas aeruginosa in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in chronic otitis media, Staphylococcus aureus in chronic rhinosinusitis and enteropathogenic Escherichia coli in recurrent urinary tract infections, are linked to biofilm formation. Biofilms are usually defined as surface-associated microbial communities, surrounded by an extracellular polymeric substance (EPS) matrix. Biofilm formation has been demonstrated for numerous pathogens and is clearly an important microbial survival strategy. However, outside of dental plaques, fewer reports have investigated biofilm development in clinical samples. Typically biofilms are found in chronic diseases that resist host immune responses and antibiotic treatment and these characteristics are often cited for the ability of bacteria to persist in vivo. This review examines some recent attempts to examine the biofilm phenotype in vivo and discusses the challenges and implications for defining a biofilm phenotype.Keywords
This publication has 93 references indexed in Scilit:
- Polymicrobial interactions stimulate resistance to host innate immunity through metabolite perceptionProceedings of the National Academy of Sciences, 2009
- ChronicPseudomonas aeruginosaInfection in Chronic Obstructive Pulmonary DiseaseClinical Infectious Diseases, 2008
- Localized Gene Expression in Pseudomonas aeruginosa BiofilmsApplied and Environmental Microbiology, 2008
- Utilization of an Intracellular Bacterial Community Pathway inKlebsiella pneumoniaeUrinary Tract Infection and the Effects of FimK on Type 1 Pilus ExpressionInfection and Immunity, 2008
- MUC2 Expression in Human Middle Ear Epithelium of Patients With Otitis MediaJAMA Otolaryngology–Head & Neck Surgery, 2008
- Filamentation byEscherichia colisubverts innate defenses during urinary tract infectionProceedings of the National Academy of Sciences, 2006
- A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilmsProceedings of the National Academy of Sciences, 2006
- Switch from planktonic to sessile life: a major event in pneumococcal pathogenesisMolecular Microbiology, 2006
- Direct Detection of Bacterial Biofilms on the Middle-Ear Mucosa of Children With Chronic Otitis MediaJAMA, 2006
- Neutrophil Extracellular Traps Kill BacteriaScience, 2004