Freeze drying of pharmaceuticals in vials: Influence of freezing protocol and sample configuration on ice morphology and freeze-dried cake texture
- 16 September 2006
- journal article
- Published by Elsevier BV in Chemical Engineering and Processing - Process Intensification
- Vol. 46 (7), 666-674
- https://doi.org/10.1016/j.cep.2006.09.003
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- A Direct Characterization Method of the Ice Morphology. Relationship Between Mean Crystals Size and Primary Drying Times of Freeze-Drying ProcessesDrying Technology, 2004
- Characterization of ice cream structure by direct optical microscopy. Influence of freezing parametersLWT, 2003
- Effects of annealing lyophilized and spray‐lyophilized formulations of recombinant human interferon‐γJournal of Pharmaceutical Sciences, 2003
- Spray‐freeze‐drying for protein powder preparation: Particle characterization and a case study with trypsinogen stabilityJournal of Pharmaceutical Sciences, 2002
- Low‐temperature electron microscopy for the study of polysaccharide ultrastructures in hydrogels. I. Theoretical and technical considerationsBiotechnology & Bioengineering, 2002
- Freeze‐drying using vacuum‐induced surface freezingJournal of Pharmaceutical Sciences, 2002
- The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature‐controlled shelfJournal of Pharmaceutical Sciences, 2001
- Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilizationJournal of Pharmaceutical Sciences, 2001
- Experimental and theoretical study of model food freezing. Part II. Characterization and modelling of the ice crystal sizeJournal of Food Engineering, 1998