Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats
- 1 October 2015
- journal article
- Published by Elsevier BV in Brain, Behavior, and Immunity
- Vol. 49, 267-279
- https://doi.org/10.1016/j.bbi.2015.06.007
Abstract
No abstract availableKeywords
Funding Information
- AHA (14POST20130024)
- Marcus Foundation
- Allen and Company
This publication has 61 references indexed in Scilit:
- Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathwayNeuroscience, 2012
- Protective and pathogenic functions of macrophage subsetsNature Reviews Immunology, 2011
- Role of Microglia in NeurotraumaNeurotherapeutics, 2010
- Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinasesExperimental Neurology, 2010
- Annexin A2 Combined with Low-Dose tPA Improves Thrombolytic Therapy in a Rat Model of Focal Embolic StrokeJournal of Cerebral Blood Flow & Metabolism, 2010
- TLR3 and TLR4 are innate antiviral immune receptors in human microglia: Role of IRF3 in modulating antiviral and inflammatory response in the CNSVirology, 2009
- Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in ratsBrain Research, 2009
- Matrix metalloproteinases as modulators of inflammationSeminars in Cell & Developmental Biology, 2007
- Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migrationThe EMBO Journal, 2006
- Statins and StrokeJournal of Cerebral Blood Flow & Metabolism, 2005