Vascular Stiffness in Women With Systemic Lupus Erythematosus
- 1 April 2001
- journal article
- other
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 37 (4), 1075-1082
- https://doi.org/10.1161/01.hyp.37.4.1075
Abstract
—Large-vessel manifestations of systemic lupus erythematosus (SLE), a multisystem disease characterized by disturbances in the immune system, include higher than expected rates of hypertension and cardiovascular disease. Reductions in the elasticity of central arteries may act as a marker of early changes that predispose to the development of major vascular disease. This study evaluated risk factors associated with aortic stiffness measured by pulse wave velocity (PWV) in women with SLE. We expected SLE-specific factors, especially variables indicative of inflammation and active disease, to be associated with increasing PWV. The study population included 220 women currently enrolled in the Pittsburgh Lupus Registry. All risk factor data were collected on the day of the ultrasound examinations. PWV waveforms were collected from the right carotid and femoral arteries by Doppler probes. The mean age of the women was 45.5±10.8 years, the median SLE disease duration approximated 9 years, and the mean PWV was 6.1±1.7 m/s. Multiple regression models were stratified by menopausal status. Among postmenopausal women, PWV risk factors were primarily traditional factors and included age, systolic blood pressure, family history of vascular disease, carotid plaque, creatinine, obesity, glucose, white cell count, and cumulative SLE organ damage. Among premenopausal women, PWV risk factors consisted of a mix of SLE-related and traditional variables and included higher C3 levels, presence of ds-DNA antibodies, nonuse of hydroxychloroquine, lower leukocyte count, higher mean arterial pressure, and carotid plaque. SLE-specific variables appeared to be associated with increases in aortic PWV, indicating central artery stiffening. This was seen most clearly among premenopausal women. This finding may partially explain the higher rates of cardiovascular disease and hypertension observed in young women with SLE.Keywords
This publication has 19 references indexed in Scilit:
- Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosusArthritis & Rheumatism, 1999
- Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy MenNew England Journal of Medicine, 1997
- Age-specific Incidence Rates of Myocardial Infarction and Angina in Women with Systemic Lupus Erythematosus: Comparison with the Framingham StudyAmerican Journal of Epidemiology, 1997
- The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosusArthritis & Rheumatism, 1996
- The antiphospholipid syndrome: ten years onThe Lancet, 1993
- Risk factors for coronary artery disease in patients with systemic lupus erythematosusAmerican Journal Of Medicine, 1992
- Molecular biology of hypertension.Hypertension, 1991
- 1989 Corcoran lecture: adaptive and maladaptive responses of the arterial wall to hypertension.Hypertension, 1990
- Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosusArthritis & Rheumatism, 1989
- Complement and arteriosclerosisAtherosclerosis, 1973