Recent developments in human immunodeficiency virus-1 latency research
Open Access
- 1 May 2013
- journal article
- review article
- Published by Microbiology Society in Journal of General Virology
- Vol. 94 (5), 917-932
- https://doi.org/10.1099/vir.0.049296-0
Abstract
Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-1) remains incurable and the virus persists due to reservoirs of latently infected CD4+memory T-cells and sanctuary sites within the infected individual where drug penetration is poor. Reactivating latent viruses has been a key strategy to completely eliminate the virus from the host, but many difficulties and unanswered questions remain. In this review, the latest developments in HIV-persistence and latency research are presented.Keywords
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