The Action of Putative Neurotransmitter Substances in the Cat Labyrinth
- 1 January 1982
- journal article
- research article
- Published by Informa UK Limited in Acta Oto-Laryngologica
- Vol. 93 (1-6), 101-105
- https://doi.org/10.3109/00016488209130858
Abstract
Possible neurotransmitter candidates were tested in the labyrinth of the cat with the aid of microiontophoretic techniques. Depending on the recording site, spontaneous regular or irregular fiber activity was obtained in the subsynaptic region of the macula sacculi. Ejection of GABA [.gamma.-aminobutyric acid] enhances the firing rate, whereas acetylcholine reduces the spontaneous activity. A similar application of glycine and proline produced no effect. The action of GABA was specifically blocked by the GABA antagonists bicuculline and picrotoxin. The alkaloids further induced a decrease in the spontaneous activity which lasted for several minutes.This publication has 14 references indexed in Scilit:
- Efferent Controlled Integrating Functions of Primary Vestibular AfferentsActa Oto-Laryngologica, 1979
- α-Bungarotoxin blocks reversibly cholinergic inhibition in the cochleaBrain Research, 1978
- Lokalisation von3H-γ-Aminobuttersäure in der CochleaPublished by Springer Science and Business Media LLC ,1974
- Neurotransmitter synthesis in inner ear and lateral line sense organsNature, 1974
- NEUROPHARMACOLOGY AND POTENTIALS OF THE INNER EARPublished by Elsevier BV ,1973
- THE SYNTHESIS OF ACETYLCHOLINE BY THE OLIVOCOCHLEAR BUNDLEJournal of Neurochemistry, 1973
- Spontaneous Activity In The Eighth Cranial Nerve of The CatInternational Journal of Neuroscience, 1972
- Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the catBrain Research, 1971
- Neurophysiological studies on hearing in goldfish.Journal of Neurophysiology, 1967
- Cholinesterase and its Relation to the Nerve Endings in the Inner EarActa Oto-Laryngologica, 1962