Stereocontrolled Synthesis of β-Difluoromethylated Materials

Abstract

Investigation of synthetic routes for regio- and stereocontrolled fluorinated materials with a difluoromethyl group, using ethyl bromodifluoroacetate as a starting material, is described. In particular, (E)-difluoromethylated trisubstituted olefins were prepared via the proton migration reaction catalyzed by using fluoride anion. Further, optically active β-difluoromethyl esters were obtained by the enzymatic resolution.