Invasive breast cancer: correlation of dynamic MR features with prognostic factors
- 26 July 2003
- journal article
- breast
- Published by Springer Science and Business Media LLC in European Radiology
- Vol. 13 (11), 2425-2435
- https://doi.org/10.1007/s00330-003-2000-y
Abstract
The purpose of this exploratory study was to correlate kinetic and morphologic MR features with histologic prognostic factors in invasive breast cancer. Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot technique. The MR characteristics were correlated with classical pathologic prognostic factors (tumor size, histologic type, grade and lymph node status) and immunohistochemically detected biomarkers [c-erbB-2, p53, Ki-67, and estrogen receptor (ER)]. Univariate and multivariate statistical analyses were performed. Presence of rim enhancement pattern, early maximal enhancement and washout phenomenon were independently associated with established predictors of poor prognosis (higher histologic grade, positive Ki-67, and negative ER status). Our results suggest that these MR signs are not only important in differentiating benign from malignant lesions, but may also be useful to noninvasively identify highly aggressive breast carcinomas.Keywords
This publication has 54 references indexed in Scilit:
- Angiogenesis in invasive breast carcinoma—a prospective study of tumour heterogeneityEuropean Journal Of Cancer, 2002
- The role of HER2 in angiogenesisSeminars in Oncology, 2001
- Prognostic Value of Vascular Endothelial Growth Factor in Breast CancerThe Oncologist, 2000
- The Ki-67 protein: From the known and the unknownJournal of Cellular Physiology, 2000
- Pathological prognostic factors in breast cancerCritical Reviews in Oncology/Hematology, 1999
- Microvessel density in invasive breast cancer assessed by dynamic gd‐dtpa enhanced MRIJournal of Magnetic Resonance Imaging, 1997
- COMMENTARY Tumour angiogenesis and prognosisHistopathology, 1997
- Angiogenesis as a Predictor of Long-term Survival for Patients With Node-Negative Breast CancerJNCI Journal of the National Cancer Institute, 1996
- Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imagingCancer, 1996
- Correlation Between Contrast Enhancement in Dynamic Magnetic Resonance Imaging of the Breast and Tumor AngiogenesisInvestigative Radiology, 1994