Growth and Tolerance of Healthy Term Infants Receiving Hydrolyzed Infant Formulas Supplemented WithLactobacillus rhamnosusGG: Randomized, Double-Blind, Controlled Trial
- 4 March 2009
- journal article
- research article
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 48 (7), 734-744
- https://doi.org/10.1177/0009922809332682
Abstract
Healthy, term infants received extensively hydrolyzed casein formula (EHF; control), the same formula supplemented with Lactobacillus rhamnosus GG (EHF-LGG), or partially hydrolyzed whey:casein (60:40) formula supplemented with LGG (PHF-LGG), in this double-blind, randomized, controlled, parallel, prospective study. Anthropometric measures and 24-hour dietary and tolerance recalls were obtained at 30, 60, 90, 120, and 150 days of age. Blood collected in a subset of infants was analyzed for fatty acid profiles in plasma and red blood cells and for markers of allergic sensitization. Adverse events were recorded throughout the study. Growth rates were not statistically different between EHF and PHF-LGG and between EHF and EHF-LGG from day 14 to day 30, 120, or 150. No relevant differences in formula tolerance, adverse events, or allergic and immune markers were demonstrated between groups. The extensively and partially hydrolyzed formulas supplemented with LGG support normal growth in healthy, term infants and are well tolerated and safe.Keywords
This publication has 35 references indexed in Scilit:
- Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trialJournal of Allergy and Clinical Immunology, 2007
- Effects of Feeding an Infant Formula Containing Lactobacillus GG on the Colonization of the IntestineJournal of Clinical Gastroenterology, 2005
- Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double‐blind placebo‐controlled trialAllergy, 2004
- Probiotics in the management of atopic eczemaClinical and Experimental Allergy, 2000
- Lactobacillus GG in the prevention of antibiotic-associated diarrhea in childrenThe Journal of Pediatrics, 1999
- Oral Bacterial Therapy Reduces the Duration of Symptoms and of Viral Excretion in Children with Mild DiarrheaJournal of Pediatric Gastroenterology and Nutrition, 1997
- Probiotics: A novel approach in the management of food allergy☆☆☆★★★Journal of Allergy and Clinical Immunology, 1997
- Oral bacteriotherapy for viral gastroenteritisDigestive Diseases and Sciences, 1994
- Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling ratsGastroenterology, 1993
- Probiotics in human medicine.Gut, 1991