Determining Lung Water Volume in Stable Hemodialysis Patients
- 1 July 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in ASAIO Journal
- Vol. 52 (4), 430-437
- https://doi.org/10.1097/01.mat.0000225269.71817.6e
Abstract
Lung water (LW) reflects the water content of the lung interstitium. Because hemodialysis patients have expanded total body water (TBW) they may also have increased LW. Hypertonic saline promotes a flux of water from lung to blood, which is measured by ultrasound flow probes on hemodialysis tubing. The volume of flux is an indirect measure of LW. Our purpose was to determine the feasibility and reproducibility of LW derived with ultrasound velocity dilution, to determine the effect of ultrafiltration on LW in stable hemodialysis patients, and to compare changes in LW with fluid compartment shifts using bioimpedance. Lung water, cardiac output, total body water, and extracellular and intracellular fluid volumes were measured in 24 stable hemodialysis patients at the beginning of hemodialysis and after ultrafiltration. The LW values at the beginning of hemodialysis (298.8 +/- 90.2 ml or 3.67 +/- 1.47 ml/kg) fell during hemodialysis (250.8 +/- 55.8 ml or 3.12 +/- 0.96 ml/kg; p < 0.05), as did TBW and extracellular fluid volumes (p < 0.001). Cardiac output, cardiac index, and central blood volume also decreased significantly with ultrafiltration (p < 0.005, p < 0.005, and p < 0.01, respectively). Results showed that stable hemodialysis patients have higher specific LW values (3.67 ml/kg) than the normal population (2 ml/kg) and ultrafiltration produces a significant decline in LW values.Keywords
This publication has 15 references indexed in Scilit:
- Measurement of Extravascular Lung Water in Hemodialysis Patients Using Blood Ultrasound Velocity and Optical Density DilutionASAIO Journal, 2002
- Effect of Crystalloid Resuscitation and Inhalation Injury on Extravascular Lung WaterChest, 2002
- Intravascular volume monitoring and extravascular lung water in septic patients with pulmonary edemaIntensive Care Medicine, 2002
- Quantification of lung microvascular injury with ultrasound.Annals of Biomedical Engineering, 2002
- Extravascular lung water in the exercising horse.Journal of Applied Physiology, 2001
- Volume of Extravascular Lung Fluid Determined by Blood Ultrasound Velocity and Electrical Impedance DilutionASAIO Journal, 1998
- Determination of cardiac output and of transcapillary fluid exchange by continuous recording of blood densityBasic Research in Cardiology, 1980
- The Application of the Density Dilution Method for the Observation of Fast Osmotic Fluid Shifts in the Lung CirculationBiomedizinische Technik/Biomedical Engineering, 1980
- Effects of posture and exercise on the pulmonary extravascular water volume in man.Journal of Applied Physiology, 1971
- Transcapillary Migrntion of Ethyl Alcohol in the Pulmonary Circulstion. A Method for Determining the Water Content of the Lungs in VivoActa Physiologica Scandinavica, 1956