The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response
Open Access
- 1 January 2012
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cellular and Infection Microbiology
- Vol. 2, 83
- https://doi.org/10.3389/fcimb.2012.00083
Abstract
The complicated interactions between Leishmania and the host antigen-presenting cells (APCs) have fundamental effects on the final outcome of the disease. Two major APCs, macrophages and dendritic cells (DCs), play critical roles in mediating resistance and susceptibility during Leishmania infection. Macrophages are the primary resident cell for Leishmania: they phagocytose and permit parasite proliferation. However, these cells are also the major effector cells to eliminate infection. The effective clearance of parasites by macrophages depends on activation of appropriate immune response, which is usually initiated by dendritic cells. Here, we review the early interaction of APCs with Leishmania parasites and how these interactions profoundly impact on the ensuing adaptive immune response. We also discuss how the current knowledge will allow further refinement of our understanding of the interplay between Leishmania and its hosts that leads to resistance or susceptibility.This publication has 87 references indexed in Scilit:
- TLR9-Dependent Activation of Dendritic Cells by DNA from Leishmania major Favors Th1 Cell Development and the Resolution of LesionsPublished by The American Association of Immunologists ,2009
- Complexities of Assessing the Disease Burden Attributable to LeishmaniasisPLoS Neglected Tropical Diseases, 2008
- Childhood visceral leishmaniasis.2006
- Leishmania lipophosphoglycan activates the transcription factor activating protein 1 in J774A.1 macrophages through the extracellular signal-related kinase (ERK) and p38 mitogen-activated protein kinaseMolecular and Biochemical Parasitology, 2005
- Dendritic Cell Populations inLeishmania major-Infected Skin and Draining Lymph NodesInfection and Immunity, 2004
- Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-γ-triggered JAK2 activationEuropean Journal of Immunology, 1999
- MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGESAnnual Review of Immunology, 1999
- The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophagesTrends in Microbiology, 1998
- Dendritic cells and the control of immunityNature, 1998
- Leishmaniasis reservoirs and their significance in controlClinics in Dermatology, 1996