Genome‐wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion
- 22 October 2008
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 143 (4), 532-536
- https://doi.org/10.1111/j.1365-2141.2008.07373.x
Abstract
Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.Keywords
This publication has 14 references indexed in Scilit:
- High density genome‐wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemiaBritish Journal of Haematology, 2008
- Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemiaBlood, 2008
- Downregulation of Death-Associated Protein Kinase 1 (DAPK1) in Chronic Lymphocytic LeukemiaCell, 2007
- Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arraysBlood, 2006
- A Chromosome 8 Gene-Cluster Polymorphism with Low Human Beta-Defensin 2 Gene Copy Number Predisposes to Crohn Disease of the ColonAmerican Journal of Human Genetics, 2006
- Loss of TP53 is due to rearrangements involving chromosome region 17p10∼p12 in chronic lymphocytic leukemiaCancer Genetics and Cytogenetics, 2006
- Characterization of target genes at the 2p15–16 amplicon in diffuse large B‐cell lymphomaCancer Science, 2006
- Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genesBlood, 2005
- Evidence for Distinct Pathomechanisms in Genetic Subgroups of Chronic Lymphocytic Leukemia Revealed by Quantitative Expression Analysis of Cell Cycle, Activation, and Apoptosis-Associated GenesJournal of Clinical Oncology, 2005
- Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphomaBlood, 2001