Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis
- 25 March 2011
- journal article
- review article
- Published by Wiley in Molecular Carcinogenesis
- Vol. 50 (4), 264-279
- https://doi.org/10.1002/mc.20665
Abstract
Growth factor receptor (GFR) signaling controls epithelial cell growth by responding to various endogenous or exogenous stimuli and subsequently activating downstream signaling pathways including Stat3, PI3K/Akt/mTOR, MAPK, and c‐Src. Environmental chemical toxicants and UVB irradiation cause enhanced and prolonged activation of GFR signaling and downstream pathways that contributes to epithelial cancer development including skin cancer. Recent studies, especially those with tissue‐specific transgenic mouse models, have demonstrated that GFRs and their downstream signaling pathways contribute to all three stages of epithelial carcinogenesis by regulating a wide variety of biological functions including proliferation, apoptosis, angiogenesis, cell adhesion, and migration. Inhibiting these signaling pathways early in the carcinogenic process results in reduced cell proliferation and survival, leading to decreased tumor formation. Collectively, these studies suggest that GFR signaling and subsequent downstream signaling pathways are potential targets for the prevention of epithelial cancers including skin cancer.Keywords
This publication has 214 references indexed in Scilit:
- Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4Nature Genetics, 2009
- Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applicationsNature Protocols, 2009
- Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesisMolecular Carcinogenesis, 2007
- AKT/PKB Signaling: Navigating DownstreamCell, 2007
- The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismNature Reviews Genetics, 2006
- Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisNature Reviews Cancer, 2006
- Molecular determinants of Akt-induced keratinocyte transformationOncogene, 2005
- Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasisOncogene, 2004
- Targeting RAS signalling pathways in cancer therapyNature Reviews Cancer, 2003
- Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityNature, 1987