THE PARTICIPATION OF BONE IN TOTAL BODY SODIUM METABOLISM IN THE RAT 1
Open Access
- 1 July 1955
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 34 (7 Pt 1), 997-1004
- https://doi.org/10.1172/jci103168
Abstract
The Na content of the inorganic phase of bone decreased by 30% in rats made acidotic and depleted of Na by dialysis against NH4Cl. By measurement of Na in bone, serum, and total carcass it was found that 50% of total Na loss came from extracellular water, 30% from bone, and 20% from intracellular water (muscle). Induction of acidosis without marked Na loss by treatment with acetazoleamide led to a 30% decrease in bone Na. No restoration of bone Na occurred after parenteral or oral repair of acidotic rats for periods up to 5 days.Keywords
This publication has 21 references indexed in Scilit:
- Potassium and Sodium Balance in Mammalian Red CellsScience, 1954
- THE RELATIONSHIP OF SODIUM AND POTASSIUM TO CARBONATE IN BONEJournal of Biological Chemistry, 1954
- ELECTROLYTE COMPOSITION OF BONE AND THE PENETRATION OF RADIOSODIUM AND DEUTERIUM OXIDE INTO DOG AND HUMAN BONE 12JCI Insight, 1954
- THE DIRECT MEASUREMENT OF THE EXTRACELLULAR PHASE OF TISSUES 12JCI Insight, 1953
- Tissue Electrolyte Changes of the Whole Body, Muscle, Erythrocyte and Plasma of Rats on a Potassium Deficient DietAmerican Journal of Physiology-Legacy Content, 1952
- Observations on the metabolic and clinical effects of carbonic-anhydrase inhibitors in epileptics.1952
- The application of the internal standard flame photometer to the analysis of biologic material.1951
- Dynamic Aspects of Sodium Metabolism in Experimental Adrenal Insufficiency Using Radioactive SodiumAmerican Journal of Physiology-Legacy Content, 1951
- THE SURFACE CHEMISTRY OF BONE .2. FLUORIDE DEPOSITION1950
- THE RELATION OF SERUM BICARBONATE CONCENTRATION TO MUSCLE COMPOSITION 1JCI Insight, 1948