Bone Mineral Status Measured by Direct Photon Absorptiometry in Childhood Renal Disease
- 1 December 1977
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 60 (6), 864-872
- https://doi.org/10.1542/peds.60.6.864
Abstract
Bone width (BW), bone mineral content (BMC), and their ratio (BMC/BW ratio) were measured in renal patients using direct photon absorptiometry. Serial measurements were made on the radius and ulna in 74 children with renal diseases. Values were compared to age-, sex-, height-, and weight-matched controls. The SD from the mean in normal subjects is ± 10%. Significant demineralization (> -2 SD) was found in 42% of all patients and in 75% with tubulointerstitial disease. Twelve patients with nephrotic syndrome and two with systemic lupus erythematosus, all of whom were receiving prednisone therapy and had a serum creatinine level less than 1.0 mg/dl, and three treated with anticonvulsants had significant demineralization. Severe demineralization (> -3 SD) was found in four rachitic patients with tubulointerstitial disease. Normal mineralization was present in 32 patients with various primary glomerular diseases, seven of whom had a serum creatinine level greater than 1.5 mg/dl. BMC declined with daily prednisone therapy but increased with alternate-day dosage in seven patients. This study suggests that demineralization is more common in patients with tubulointerstitial disease and in patients with primary glomerular disease who are receiving prednisone (16 patients) or anticonvulsants. Photon absorptiometry appeared more useful than conventional radiographic evaluation in assessing skeletal involvement in childhood renal disease.Keywords
This publication has 6 references indexed in Scilit:
- Impaired renal conservation of sodium and chloride during sustained correction of systemic acidosis in patients with type 1, classic renal tubular acidosis.JCI Insight, 1976
- Recent advances in calcium metabolismThe Journal of Pediatrics, 1976
- Accuracy of Bone Mineral MeasurementScience, 1964
- Measurement of Bone Mineral in vivo: An Improved MethodScience, 1963
- Active transport of calcium by intestine: effects of dietary calciumAmerican Journal of Physiology-Legacy Content, 1961
- Transfer of Ca45 across intestinal wall in vitro in relation to action of vitamin D and cortisolAmerican Journal of Physiology-Legacy Content, 1960