Short Communication: Intracellular Glutathione as a Possible Direct Blocker of HIV Type 1 Reverse Transcription
- 20 November 1996
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 12 (17), 1635-1638
- https://doi.org/10.1089/aid.1996.12.1635
Abstract
In AIDS patients, chronic inflammation and elevated levels of cytokines seem to be associated with reduced levels of glutathione (GSH). GSH has been proposed to inhibit the activation of NF-κB, which results in the inhibition of HIV-1 replication. Here, we show the evidence that GSH and N-acetylcysteine, but not l-cysteine or dithiothreitol, could inhibit the reverse transcriptase (RT) process of HIV-1. Such inhibition was not observed with the RT of murine leukemia virus.Keywords
This publication has 32 references indexed in Scilit:
- Nonsense mutations in the vpr gene of HIV‐1 during in vitro virus passage and in HIV‐1 carrier‐derived peripheral blood mononuclear cellsFEBS Letters, 1994
- Glutathione Precursor and Antioxidant Activities ofN-Acetylcysteine and Oxothiazolidine Carboxylate Compared inin VitroStudies of HIV ReplicationAIDS Research and Human Retroviruses, 1994
- Modulatory effect of
acetyl- on the HIV-1 multiplication in chronically and acutely infected cell linesl -cysteineAntiviral Research, 1993 - Superoxide enhances the spread of HIV‐1 infection by cell‐to‐cell transmissionFEBS Letters, 1993
- Amplification of superoxide anion generation in phagocytic cells by HIV-1 infectionFEBS Letters, 1993
- Antioxidants Inhibit Stimulation of HIV TranscriptionAIDS Research and Human Retroviruses, 1993
- Thiol suppression of human immunodeficiency virus type 1 replication in primary cord blood monocyte-derived macrophages in vitro.JCI Insight, 1993
- Glutathione and N-Acetylcysteine Suppression of Human Immunodeficiency Virus Replication in Human Monocyte/Macrophages In VitroAIDS Research and Human Retroviruses, 1992
- N-Acetylcysteine Inhibits Latent HIV Expression in Chronically Infected CellsAIDS Research and Human Retroviruses, 1991
- Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected PatientsBiological Chemistry Hoppe-Seyler, 1989