Genetically Determined Response to Different Ingested Carbohydrates in the Production of Diabetes

Abstract

It has been shown that the metabolic responses to the ingestion of carbohydrates depend upon a) the type of the ingested carbohydrate and b) the genetic build-up of the recipient. In the non-susceptible animal, the ingestion of high sucrose, fructose or glucose diets will ensue in "normal" metabolic responses. In the susceptible animal the ingestion of these same carbohydrates will result in impairment of the carbohydrate and lipid metabolism, which will ultimately lead to the development of diabetes and diabetic angiopathy while their siblings with the same genetic build-up consuming starch, will not. The impairment of the carbohydrate and lipid metabolism by high glucose diet was such smaller than that by fructose or sucrose.