Invasive Non-AspergillusMold Infections in Transplant Recipients, United States, 2001–2006
Open Access
- 1 October 2011
- journal article
- research article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 17 (10), 1855-1864
- https://doi.org/10.3201/eid1710.110087
Abstract
Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.Keywords
This publication has 35 references indexed in Scilit:
- Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantationBlood, 2010
- Geoclimatic Influences on Invasive Aspergillosis after Hematopoietic Stem Cell TransplantationClinical Infectious Diseases, 2010
- Improving Molecular Detection of Fungal DNA in Formalin-Fixed Paraffin-Embedded Tissues: Comparison of Five Tissue DNA Extraction Methods Using Panfungal PCRJournal of Clinical Microbiology, 2010
- Zygomycosis in Solid Organ Transplant Recipients: A Prospective, Matched Case‐Control Study to Assess Risks for Disease and OutcomeThe Journal of Infectious Diseases, 2009
- Increasing Incidence of Zygomycosis (Mucormycosis), France, 1997–2006Emerging Infectious Diseases, 2009
- Epidemiology of Invasive Mold Infections in Allogeneic Stem Cell Transplant Recipients: Biological Risk Factors for Infection According to Time after TransplantationClinical Infectious Diseases, 2008
- Comparison of the Use of Administrative Data and an Active System for Surveillance of Invasive AspergillosisInfection Control & Hospital Epidemiology, 2008
- Zygomycosis in a Tertiary‐Care Cancer Center in the Era ofAspergillus‐Active Antifungal Therapy: A Case‐Control Observational Study of 27 Recent CasesThe Journal of Infectious Diseases, 2005
- Sinus zygomycosis in a patient receiving voriconazole prophylaxisBritish Journal of Haematology, 2005
- Breakthrough Zygomycosis after Voriconazole Treatment in Recipients of Hematopoietic Stem-Cell TransplantsNew England Journal of Medicine, 2004