A Butyrophilin Family Member Critically Inhibits T Cell Activation
Open Access
- 15 November 2010
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 185 (10), 5907-5914
- https://doi.org/10.4049/jimmunol.1000835
Abstract
The costimulatory molecules in the B7-CD28 families are important in the regulation of T cell activation and tolerance. The butyrophilin family of proteins shares sequence and structure homology with B7 family molecules; however, the function of the butyrophilin family in the immune system has not been defined. In this study, we performed an analysis on multiple butyrophilin molecules and found that butyrophilin-like (BTNL)1 molecule functions to dampen T cell activation. BTNL1 mRNA was broadly expressed, but its protein was only found in APCs and not T cells. The putative receptor for BTNL1 was found on activated T cells and APCs. Also, recombinant BTNL1 molecule inhibited T cell proliferation by arresting cell cycle progression. The administration of neutralizing Abs against BTNL1 provoked enhanced T cell activation and exacerbated disease in autoimmune and asthma mouse models. Therefore, BTNL1 is a critical inhibitory molecule for T cell activation and immune diseases.Keywords
This publication has 29 references indexed in Scilit:
- BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell ActivationPublished by The American Association of Immunologists ,2010
- Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responsesProceedings of the National Academy of Sciences, 2008
- Regulation of inflammatory responses by IL-17FThe Journal of Experimental Medicine, 2008
- Inhibitory costimulation and anti-tumor immunitySeminars in Cancer Biology, 2007
- T-cell tolerance or function is determined by combinatorial costimulatory signalsThe EMBO Journal, 2006
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Nature Immunology, 2005
- THE B7 FAMILY REVISITEDAnnual Review of Immunology, 2005
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammationThe Journal of Experimental Medicine, 2005
- Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cellsEuropean Journal of Immunology, 2004
- The Cluster of BTN Genes in the Extended Major Histocompatibility ComplexGenomics, 2001