Innate and adaptive immune responses in asthma
Top Cited Papers
- 4 May 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 18 (5), 673-683
- https://doi.org/10.1038/nm.2731
Abstract
The recognition that asthma is primarily an inflammatory disorder of the airways associated with T helper type 2 (TH2) cell-dependent promotion of IgE production and recruitment of mast cells and eosinophils has provided the rationale for disease control using inhaled corticosteroids and other anti-inflammatory drugs. As more has been discovered about the cytokine, chemokine and inflammatory pathways that are associated with TH2-driven adaptive immunity, attempts have been made to selectively inhibit these in the hope of discovering new therapeutics as predicted from animal models of allergic inflammation. The limited success of this approach, together with the recognition that asthma is more than allergic inflammation, has drawn attention to the innate immune response in this disease. Recent advances in our understanding of the sentinel role played by innate immunity provides new targets for disease prevention and treatment. These include pathways of innate stimulation by environmental or endogenous pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) to influence the activation and trafficking of DCs, innate sources of cytokines, and the identification of new T cell subsets and lymphoid cells.Keywords
This publication has 152 references indexed in Scilit:
- A genome-wide association study of plasma total IgE concentrations in the Framingham Heart StudyJournal of Allergy and Clinical Immunology, 2011
- Spatiotemporal and Functional Behavior of Airway Dendritic Cells Visualized by Two-Photon MicroscopyThe American Journal of Pathology, 2011
- Making sense of regulatory T cell suppressive functionSeminars in Immunology, 2011
- Functional Specialization of Interleukin-17 Family MembersImmunity, 2011
- Role and mechanism of action of complement in regulating T cell immunityMolecular Immunology, 2010
- IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcγRIIA and FcγRIIBImmunology Letters, 2010
- Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstructionMucosal Immunology, 2010
- Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitisJournal of Allergy and Clinical Immunology, 2010
- IL-17–producing T cells in lung immunity and inflammationJournal of Allergy and Clinical Immunology, 2009
- Pathogen Recognition and Innate ImmunityCell, 2006