Antiganglioside Antibodies Inhibit Neuritic Outgrowth from Regenerating Goldfish Retinal Explants
- 1 September 1982
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 39 (3), 874-877
- https://doi.org/10.1111/j.1471-4159.1982.tb07974.x
Abstract
Antibodies elicited in rabbits against bovine brain gangliosides were applied to regenerating retinal explants to examine the role of gangliosides in the trophic effect responsible for the induction of outgrowth. Antibodies specific to gangliosides block the neuritic outgrowth from the regenerating retinal explants. It is inferred that gangliosides function as receptors on the cell surface of the retinal explants that interact with the trophic substances inducing the outgrowth. The relevance of gangliosides to the mechanism of regeneration and development induced by trophic factors is discussed.Keywords
This publication has 20 references indexed in Scilit:
- Antibodies to Gangliosides and Myelin Autoantigens Are Produced in Mice Following Sciatic Nerve InjuryJournal of Neurochemistry, 1982
- Factor(s) from goldfish brain induce neuritic outgrowth from explanted regenerating retinasDevelopmental Brain Research, 1982
- Regenerating goldfish retinal explants: Induction and maintenance of neurites by conditioned medium from cells originated in the nervous systemDevelopmental Brain Research, 1982
- The retina as a biochemical model of central nervous system regenerationNeurochemistry International, 1980
- Nerve Growth Factor: Biological Significance, Measurement and DistributionJournal of Neurochemistry, 1980
- Treatment of denervated muscle by gangliosidesMuscle & Nerve, 1979
- Growth factors and gangliosides: A possible new perspective in neuronal growth controlJournal of Supramolecular Structure, 1979
- Induction of anti-idiotypic antibodies by immunisation with syngeneic spleen cells educated with acetylcholine receptorNature, 1978
- The nerve cell body response to axotomyExperimental Neurology, 1975
- GANGLIOSIDE ABNORMALITIES IN MULTIPLE SCLEROSISJournal of Neurochemistry, 1974