PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma
Top Cited Papers
- 26 July 2018
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 379 (4), 341-351
- https://doi.org/10.1056/nejmoa1805131
Abstract
No systemic therapies have been approved for the treatment of advanced cutaneous squamous-cell carcinoma. This cancer may be responsive to immune therapy, because the mutation burden of the tumor is high and the disease risk is strongly associated with immunosuppression. In the dose-escalation portion of the phase 1 study of cemiplimab, a deep and durable response was observed in a patient with metastatic cutaneous squamous-cell carcinoma.Keywords
Funding Information
- Regeneron Pharmaceuticals, Inc. (N/A)
- Sanofi (N/A)
This publication has 22 references indexed in Scilit:
- Advanced cutaneous squamous cell carcinoma: A retrospective analysis of patient profiles and treatment patterns—Results of a non-interventional study of the DeCOGEuropean Journal Of Cancer, 2018
- Systemic Therapy in Advanced Cutaneous Squamous Cell Carcinoma (CSCC)American Journal of Clinical Oncology, 2016
- Consensus for Nonmelanoma Skin Cancer Treatment, Part IIDermatologic Surgery, 2015
- Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012JAMA Dermatology, 2015
- Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guidelineEuropean Journal Of Cancer, 2015
- Mutational Landscape of Aggressive Cutaneous Squamous Cell CarcinomaClinical Cancer Research, 2014
- Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012Journal of the American Academy of Dermatology, 2013
- A systematic review of worldwide incidence of nonmelanoma skin cancerBritish Journal of Dermatology, 2012
- Treatment of Unresectable and Metastatic Cutaneous Squamous Cell CarcinomaThe Oncologist, 2010
- Skin Cancers after Organ TransplantationNew England Journal of Medicine, 2003