Peripheral neuropathy with IgM kappa monoclonal immunoglobulin directed against myelin‐associated glycoprotein
- 1 November 1983
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 33 (11), 1397
- https://doi.org/10.1212/wnl.33.11.1397
Abstract
Three patients with a monoclonal IgM kappa paraproteinemia had a slowly progressive segmental demyelinating peripheral neuropathy. Sural nerve biopsies showed predominantly large fiber loss, with widening of the intraperiod line of myelin associated with active demyelination. Immunoblot analysis showed reactivity of IgM to myelin-associated glycoprotein (MAG) of human myelin. An enzyme-linked immunosorbent assay (ELISA) was developed to provide a simple quantitative technique for detection of antibodies to MAG. Treatment with corticosteroids, immunosup-pressive agents, and plasmapheresis produced no significant improvement.This publication has 17 references indexed in Scilit:
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