A Synthetic Hexadecapeptide Derived from Allergen M Imposing Allergenic and Antigenic Reactivity
- 1 August 1980
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 12 (2), 171-175
- https://doi.org/10.1111/j.1365-3083.1980.tb00055.x
Abstract
A solid phase synthesis (SPPS) hexadecapeptide corresponding to residues 49-64 of allergen M from cod specifically bound IgE antibodies from sera of cod-allergic individuals. The SPPS peptide was similarly reactive in IgG-mediated reactions; it could interfere with Allergen M line precipitate in rocket-line immunoelectrophoresis, giving a distinct deflection. It is the only reported synthetic polypeptide imposing allergenic and antigenic reactivity. The hexadecapeptide is composed of 2 homologous tetrapeptides located at its termini, tentatively concluded to be mutually critical for the immunological specificity. The predicted reactivity of the Ca2+-binding CD loop of the intact Allergen M was confirmed.This publication has 14 references indexed in Scilit:
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