Role of malaria induced oxidative stress on anaemia in pregnancy

Abstract

Objective: To assess the role of oxidative stress on anaemia in pregnancy. Methods: Blood samples were collected from pregnant and non-pregnant women who came for antenatal clinic and medical check at Comprehensive Health Center, Akungba-Akoko and Iwaro General Hospital in Akoko Area of Ondo State, Nigeria. Thick and thin blood films were prepared and used for malaria parasite counts. Haemoglobin level was determined by colorimetric method using Drabkin's solution. Oxidative status was determined using malondiadelhyde level as an indicator of lipid peroxidation, while ascorbic acid and reduced glutathione levels were measured by standard spectrophotometric methods. Results: Mean parasite density was significantly higher in pregnant women than non-pregnant women (Pr = 0.53). The Hb level decreased as the parasite density and MDA level increased in pregnant women. Conclusions: This study shows that oxidative stress, caused by malaria infection could be part of the contributing factors responsible for anaemia in pregnancy.