Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death
- 1 February 2013
- journal article
- Published by Elsevier BV in Neurobiology of Disease
- Vol. 50, 160-170
- https://doi.org/10.1016/j.nbd.2012.10.015
Abstract
No abstract availableKeywords
Funding Information
- STEM-HD (EU-FP6)
- Fondazione Cariplo
- NIH (NINDS 32765)
- Huntington's Disease Society of America Coalition for the Cure
- Unicredit Banca S.p.A
- Tavola Valdese
This publication has 58 references indexed in Scilit:
- The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activityNeurobiology of Disease, 2012
- A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's diseaseJournal of Neurophysiology, 2012
- Systematic Chromosomal Analysis of Cultured Mouse Neural Stem Cell LinesStem Cells and Development, 2011
- Erratum: Neural stem cell systems: physiological players or in vitro entities?Nature Reviews Neuroscience, 2010
- CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 miceMolecular and Cellular Neuroscience, 2008
- Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: Restoration by the neuroprotective compound CEP-1347Molecular and Cellular Neuroscience, 2008
- Normal huntingtin function: an alternative approach to Huntington's diseaseNature Reviews Neuroscience, 2005
- Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem CellPLoS Biology, 2005
- Loss of normal huntingtin function: new developments in Huntington's disease researchTrends in Neurosciences, 2001
- Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell cultureHuman Molecular Genetics, 1998