Transition-Metal-Free Indirect Friedländer Synthesis of Quinolines from Alcohols
- 21 October 2008
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 73 (24), 9778-9780
- https://doi.org/10.1021/jo801678n
Abstract
The synthesis of polysubstituted quinolines can be easily and greenly accomplished by the direct reaction between the corresponding 2-aminobenzylic alcohol derivative and either a ketone or alcohol in the presence of a base, without any transition-metal catalyst.Keywords
This publication has 41 references indexed in Scilit:
- Borrowing Hydrogen in the Activation of AlcoholsAdvanced Synthesis & Catalysis, 2007
- Topical Imiquimod Treatment Prevents UV-Light Induced Loss of Contact Hypersensitivity and Immune ToleranceJournal of Investigative Dermatology, 2006
- Mechanistic aspects of transition metal-catalyzed hydrogen transfer reactionsChemical Society Reviews, 2006
- Asymmetric transfer hydrogenation: chiral ligands and applicationsChemical Society Reviews, 2005
- Functionalized magnesium organometallics as versatile intermediates for the synthesis of polyfunctional heterocyclesChemical Communications, 2005
- A rhodium-catalyzed route for oxidative coupling and cyclization of 2-aminobenzyl alcohol with ketones leading to quinolinesJournal of Heterocyclic Chemistry, 2005
- Polyquinolines and polyanthrazolines: synthesis and propertiesRussian Chemical Reviews, 2005
- TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 CellsJournal of Pharmacology and Experimental Therapeutics, 2003
- Uncatalysed hydrogen-transfer reductions of aldehydes and ketonesChemical Communications, 1999
- Friedländer syntheses with o‐aminoaryl ketones. III. Acid‐catalyzed condensations of o‐aminobenzophenone with polyfunctional carbonyl compoundsJournal of Heterocyclic Chemistry, 1967