Oxidant Signaling in Vascular Cell Growth, Death, and Survival
Top Cited Papers
- 4 August 2000
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 87 (3), 179-183
- https://doi.org/10.1161/01.res.87.3.179
Abstract
Reactive oxygen species (ROS) have been traditionally regarded as toxic byproducts of aerobic metabolism. However, ROS can also act as intracellular signaling molecules in vascular cells. ROS can mediate phenotypes in vascular endothelial and smooth muscle cells that may be considered both physiological and pathophysiological. Among these are growth, apoptosis, and survival. The specific response elicited by reactive oxygen intermediaries is determined by their specific intracellular target(s). This, in turn, is dependent on the species of oxidant(s) produced, the source and therefore subcellular localization of the oxidant(s), the kinetics of production, and the quantities produced. A fuller understanding of how ROS regulate mitogenesis and apoptosis in vascular smooth muscle and endothelial cells will permit the development of novel strategies to modify or prevent vascular diseases in which these phenotypes predominate.Keywords
This publication has 48 references indexed in Scilit:
- NF-κB Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-α but Not to Interleukin-1β or LipopolysaccharidePublished by Elsevier BV ,1999
- Generation of reactive oxygen intermediates, activation of NF-κB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?Free Radical Biology & Medicine, 1999
- VEGF Prevents Apoptosis of Human Microvascular Endothelial Cells via Opposing Effects on MAPK/ERK and SAPK/JNK SignalingExperimental Cell Research, 1999
- p38 Mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule–1 up-regulation on human pulmonary microvascular endothelial cellsSurgery, 1998
- Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosisNature, 1996
- Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells.JCI Insight, 1995
- Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cellsBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1995
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitroBiochemical and Biophysical Research Communications, 1992
- Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane EnzymesScience, 1991