Central Hypotensive Effects of the α 2a -Adrenergic Receptor Subtype
- 9 August 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5276), 801-803
- https://doi.org/10.1126/science.273.5276.801
Abstract
α2-Adrenergic receptors (α2ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three α2AR subtypes, the lack of subtype-specific ligands, and the cross-reactivity of α2AR agonists with imidazoline receptors has precluded an understanding of the role of individual α2AR subtypes in the hypotensive response. Gene targeting was used to introduce a point mutation into the α2aAR subtype in the mouse genome. The hypotensive response to α2AR agonists was lost in the mutant mice, demonstrating that the α2aAR subtype plays a principal role in this response.Keywords
This publication has 10 references indexed in Scilit:
- Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and cScience, 1996
- .alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. Part 1. Molecular Biology and Adrenoceptor SubclassificationJournal of Medicinal Chemistry, 1995
- Agmatine: an Endogenous Clonidine-Displacing Substance in the BrainScience, 1994
- Distribution of α2-adrenergic receptor subtype gene expression in rat brainMolecular Brain Research, 1994
- Expression of multiple alpha adrenergic receptor subtype messenger RNAs in the adult rat brainNeuroscience, 1993
- Pharmacologic and Therapeutic Applications of alpha2-Adrenoceptor SubtypesAnnual Review of Pharmacology and Toxicology, 1993
- Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization studyJournal of Comparative Neurology, 1993
- [51] Gene targeting in embryonic stem cellsMethods in enzymology, 1993
- A Point Mutation of the α 2 -Adrenoceptor that Blocks Coupling to Potassium but not Calcium CurrentsScience, 1992
- Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceCell, 1991