Recombination hot spot in the human beta-globin gene cluster: meiotic recombination of human DNA fragments in Saccharomyces cerevisiae.
Open Access
- 1 August 1985
- journal article
- research article
- Published by Informa UK Limited in Molecular and Cellular Biology
- Vol. 5 (8), 2029-2038
- https://doi.org/10.1128/mcb.5.8.2029
Abstract
We describe a novel system for the analysis of sequence-specific meiotic recombination in Saccharomyces cerevisiae. A comparison of three adjacent restriction fragments from the human beta-globin locus revealed that one of them, previously hypothesized to contain a relative hot spot for genetic recombination, engages in reciprocal exchange during yeast meiosis significantly more frequently than either of the other two fragments. Removal of the longest of four potential Z-DNA-forming regions from this fragment does not affect the high frequency of genetic recombination.This publication has 55 references indexed in Scilit:
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