LRRK2 G2019S founder haplotype in the Chinese population
- 1 January 2007
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 22 (1), 105-107
- https://doi.org/10.1002/mds.21206
Abstract
The G2019S mutation in the LRRK2 (leucine‐rich repeat kinase) gene appears very rarely in the Chinese population. Among Chinese subjects who were non‐G2019S carriers, we demonstrated the frequency of the LRRK2 G2019S founder haplotype (T‐254‐A‐G‐A‐154) in Parkinson's disease and controls to be 33% and 30%. This rate is similar to the frequency in European noncarriers, indirectly supporting the association of this haplotype with G2019S carriers. The haplotype is likely to be more ancient than the G2019S mutation because it is also found in a population with a very low carrier rate. © 2006 Movement Disorder SocietyKeywords
This publication has 17 references indexed in Scilit:
- LRRK2G2019S as a Cause of Parkinson's Disease in North African ArabsNew England Journal of Medicine, 2006
- LRRK2G2019S as a Cause of Parkinson's Disease in Ashkenazi JewsNew England Journal of Medicine, 2006
- G2019S LRRK2 mutation in French and North African families with Parkinson's diseaseAnnals of Neurology, 2005
- LRRK2 Haplotype Analyses in European and North African Families with Parkinson Disease: A Common Founder for the G2019S Mutation Dating from the 13th CenturyAmerican Journal of Human Genetics, 2005
- The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patientsNeuroscience Letters, 2005
- Clinical features of LRRK2‐associated Parkinson's disease in central NorwayAnnals of Neurology, 2005
- Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European PopulationsAmerican Journal of Human Genetics, 2005
- A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's diseaseThe Lancet, 2005
- Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's DiseaseNeuron, 2004
- Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic PathologyNeuron, 2004