Therapeutic Effects of Fucoidan: A Review on Recent Studies
Top Cited Papers
Open Access
- 20 August 2019
- journal article
- review article
- Published by MDPI AG in Marine Drugs
- Vol. 17 (9), 487
- https://doi.org/10.3390/md17090487
Abstract
Fucoidan is a polysaccharide largely made up of l-fucose and sulfate groups. Fucoidan is favorable worldwide, especially amongst the food and pharmaceutical industry as a consequence of its promising therapeutic effects. Its applaudable biological functions are ascribed to its unique biological structure. Classical bioactivities associated with fucoidan include anti-oxidant, anti-tumor, anti-coagulant, anti-thrombotic, immunoregulatory, anti-viral and anti-inflammatory effects. More recently, a variety of in vitro and in vivo studies have been carried out to further highlight its therapeutic potentials. This review focuses on the progress towards understanding fucoidan and its biological activities, which may be beneficial as a future therapy. Hence, we have summarized in vitro and in vivo studies that were done within the current decade. We expect this review and a variety of others can contribute as a theoretical basis for understanding and inspire further product development of fucoidan.Keywords
Funding Information
- National Natural Science Foundation of China (LY18C020006, 41876197, 31470430 and 81872952)
- Science and Technology Program of Wenzhou (Y20180210)
This publication has 75 references indexed in Scilit:
- Fucoidans as Potential Inhibitors of HIV-1Marine Drugs, 2013
- Lessons from the History of Quarantine, from Plague to Influenza AEmerging Infectious Diseases, 2013
- Stigma, Health Disparities, and the 2009 H1N1 Influenza Pandemic: How to Protect Latino Farmworkers in Future Health EmergenciesBiosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, 2010
- Hepatitis B: The virus and diseaseHepatology, 2009
- Inhibitory Effect of Fucoidan on Huh7 Hepatoma Cells Through Downregulation of CXCL12Nutrition and Cancer, 2009
- Pathogenesis and immunopathology of systemic and nervous canine distemperVeterinary Immunology and Immunopathology, 2009
- Heparin-Induced ThrombocytopeniaCell Metabolism, 2006
- Isolation and Culture of a Marine Bacterium Degrading the Sulfated Fucans from Marine Brown AlgaeMarine Biotechnology, 2006
- Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studiesCarbohydrate Research, 2002
- Cerebral hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits.Stroke, 1991