Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence
Open Access
- 6 October 2000
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 14 (15), 2495-2502
- https://doi.org/10.1096/fj.00-0209com
Abstract
Oxidized and cross-linked proteins tend to accumulate in aging cells. Declining activity of proteolytic enzymes, particularly the proteasome, has been proposed as a possible explanation for this phen...Keywords
Funding Information
- National Institutes of Health (ES03598)
This publication has 42 references indexed in Scilit:
- Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cellsThe FASEB Journal, 2000
- Proteasome‐dependent degradation of oxidized proteins in MRC‐5 fibroblastsFEBS Letters, 1998
- Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by ProteasomeJournal of Biological Chemistry, 1998
- Degradation of oxidized proteins in mammalian cellsThe FASEB Journal, 1997
- Modification of protein surface hydrophobicity and methionine oxidation by oxidative systemsProceedings of the National Academy of Sciences, 1997
- Methionine residues as endogenous antioxidants in proteinsProceedings of the National Academy of Sciences, 1996
- Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by ProteasomeJournal of Biological Chemistry, 1996
- Proteolysis in Cultured Liver Epithelial Cells during Oxidative StressJournal of Biological Chemistry, 1995
- Exposure of Hydrophobic Moieties Promotes the Selective Degradation of Hydrogen Peroxide-Modified Hemoglobin by the Multicatalytic Proteinase Complex, ProteasomeArchives of Biochemistry and Biophysics, 1994
- Susceptibility of Glucose-6-Phosphate Dehydrogenase Modified by 4-Hydroxy-2-nonenal and Metal-Catalyzed Oxidation to Proteolysis by the Multicatalytic ProteaseArchives of Biochemistry and Biophysics, 1994