The development of innervation in the rat atrioventricular node
- 1 March 1977
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 178 (1), 73-82
- https://doi.org/10.1007/bf00232825
Abstract
The problem of development of the innervation of the rat atrioventricular node has been investigated by electron microscopy. Nerve bundles appear in relation to the node as early as the second postnatal day and vesiculated axons are seen throughout the entire node by the fourth day. Intimate contacts between nodal cells, axons and terminal varicosities are frequently observed. Use of the 5-hydroxydopamine tracer technique has enabled the identification of both cholinergic and adrenergic axons. It is concluded that the node has a dual innervation although cholinergic endings far outnumber those classified as adrenergic on the sixth postnatal day. These results are quite different to earlier findings made at the light microscope level and the discrepancies are discussed with respect to the histochemical techniques used. The suggestion that nodal differentiation is induced by nerves is considered in relation to the differences in cholinesterase activity exhibited by nodal cells during normal development and following neonatal sympathectomy.This publication has 19 references indexed in Scilit:
- CHOLINESTERASE AND THE ATRIOVENTRICULAR NODE AND BUNDLE IN THE HUMAN FETUS UP TO MIDTERMJournal of Histochemistry & Cytochemistry, 1973
- Fine structure of the atrioventricular node as viewed in serial sectionsJournal of Anatomy, 1973
- Histologic and histochemical evidence concerning the presence of morphologically distinct cellular zones within the rabbit atrioventricular nodeThe Anatomical Record, 1972
- Electron Microscopy of the Heart Conduction System of the DogArchivum histologicum japonicum, 1971
- Atrioventricular node innervation in ultrastructural three dimensionsJournal of Anatomy, 1970
- Recent Developments on the Ultrastructural Aspect of Adrenergic Nerve Endings in Various Experimental ConditionsProgress in brain research, 1969
- Electron Microscopic Identification of Autonomic Nerve EndingsNature, 1966
- ONTOGENESIS OF CHOLINESTERASE ACTIVITY WITHIN HEART AND CARDIAC GANGLIA IN MAN RAT RABBIT AND GUINEA-PIG1965
- THE SINU‐ATRIAL NODE OF THE RAT HEARTQuarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1955
- Intrinsic contractility in the embryonic rat heartThe Anatomical Record, 1951