Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-Like Tyrosine Kinase-1 and Soluble Endogline in Preeclampsia
- 1 August 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 52 (2), 402-407
- https://doi.org/10.1161/hypertensionaha.108.115006
Abstract
Deficient NO formation has been implicated in hypertensive disorders of pregnancy. However, no previous study has compared the circulating nitrite concentrations in healthy pregnant women with those found in hypertensive disorders of pregnancy. Moreover, 2 antiangiogenic factors produced in the placenta (soluble fms-like tyrosine kinase-1 and soluble endogline) may affect NO formation during pregnancy. Here, we hypothesized that lower concentrations of markers of NO formation exist in hypertensive disorders of pregnancy and that inverse relationships exist between these markers and soluble fms-like tyrosine kinase-1 or soluble endogline. In this cross-sectional study, we compared 58 healthy pregnant women with 56 gestational hypertensive subjects and 45 preeclamptic patients. We measured plasma and whole blood nitrite concentrations using an ozone-based chemiluminescence assay and serum soluble fms-like tyrosine kinase-1 and soluble endogline concentrations using enzyme immunoassays. Whole blood nitrite levels were significantly lower in gestational hypertensive subjects and preeclamptic patients (−36% and −58%, respectively; both P P P r from −0.175 to −0.226; all P <0.05). Our results show clinical evidence for impaired NO formation in preeclampsia or gestational hypertension. The negative correlations between markers of NO formation and antiangiogenic factors in preeclamptic patients suggest an inhibitory effect for these factors on NO formation.Keywords
This publication has 47 references indexed in Scilit:
- Endoglin in angiogenesis and vascular diseasesAngiogenesis, 2008
- Sequential Changes in Antiangiogenic Factors in Early Pregnancy and Risk of Developing PreeclampsiaHypertension, 2007
- Molecular mechanisms of preeclampsiaMicrovascular Research, 2007
- Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2‐dependent TGF‐β signalingJournal of Cellular Physiology, 2006
- Soluble Endoglin and Other Circulating Antiangiogenic Factors in PreeclampsiaNew England Journal of Medicine, 2006
- Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritisAmerican Journal of Obstetrics and Gynecology, 2006
- Neurokinin B and nitric oxide plasma levels in pre‐eclampsia and isolated intrauterine growth restrictionBJOG: An International Journal of Obstetrics and Gynaecology, 2004
- Preeclampsia: Evidence for impaired shear stress–mediated nitric oxide release in uterine circulationAmerican Journal of Obstetrics and Gynecology, 2000
- VEGF-A Induces Expression of eNOS and iNOS in Endothelial Cells via VEGF Receptor-2 (KDR)Biochemical and Biophysical Research Communications, 1998
- Identification of a Natural Soluble Form of the Vascular Endothelial Growth Factor Receptor, FLT-1, and Its Heterodimerization with KDRBiochemical and Biophysical Research Communications, 1996