Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies
- 1 July 1994
- journal article
- Published by Springer Science and Business Media LLC in Nature Biotechnology
- Vol. 12 (7), 683-688
- https://doi.org/10.1038/nbt0794-683
Abstract
IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through gamma specific Fc receptors. Using a generalizable technique we have produced IgM-like polymers of IgG that possess both the Fc gamma receptor binding properties of IgG and the more potent complement activity of IgM.Keywords
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