Brown adipose tissue and bone
- 4 August 2015
- journal article
- review article
- Published by Springer Science and Business Media LLC in International Journal of Obesity Supplements
- Vol. 5 (S1), S23-S27
- https://doi.org/10.1038/ijosup.2015.7
Abstract
Brown adipose tissue (BAT) is capable of transforming chemically stored energy, in the form of triglycerides, into heat. Recent studies have shown that metabolically active BAT is present in a large proportion of adult humans, where its activity correlates with a favorable metabolic status. Hence, the tissue is now regarded as an interesting target for therapies against obesity and associated diseases such as type 2 diabetes, the hypothesis being that an induction of BAT would be beneficial for these disease states. Apart from the association between BAT activity and a healthier metabolic status, later studies have also shown a positive correlation between BAT volume and both bone cross-sectional area and bone mineral density, suggesting that BAT might stimulate bone anabolism. The aim of this review is to give the reader a brief overview of the BAT research field and to summarize and discuss recent findings regarding BAT being a potential player in bone metabolism.Keywords
This publication has 56 references indexed in Scilit:
- Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat MitochondriaCell, 2012
- In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat FeedingCell Metabolism, 2012
- Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanismBone, 2012
- Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetesBone, 2012
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesisNature, 2012
- Functional Brown Adipose Tissue is Related to Muscle Volume in Children and AdolescentsThe Journal of Pediatrics, 2011
- Rb regulates fate choice and lineage commitment in vivoNature, 2010
- Transcriptional Control of Brown Fat DevelopmentCell Metabolism, 2010
- Identification and Importance of Brown Adipose Tissue in Adult HumansNew England Journal of Medicine, 2009
- PRDM16 controls a brown fat/skeletal muscle switchNature, 2008