Atheroprotective Effects of High-Density Lipoproteins
- 1 February 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 54 (1), 321-341
- https://doi.org/10.1146/annurev.med.54.101601.152409
Abstract
Observational studies provide overwhelming evidence that a low high-density lipoprotein (HDL)-cholesterol level increases the risk of coronary events, both in healthy subjects and in patients with coronary heart disease. Based on in vitro experiments, several mechanistic explanations for the atheroprotective function of HDL have been suggested. However, few of these were verified in vivo in humans or in experiments with transgenic animals. The HDL functions currently most widely held to account for the antiatherogenic effect include participation in reverse cholesterol transport, protection against endothelial dysfunction, and inhibition of oxidative stress. This review summarizes current views on the molecular mechanism underlying these atheroprotective effects of HDL.Keywords
This publication has 80 references indexed in Scilit:
- Insights of High-Density Lipoprotein Apolipoprotein-Mediated Lipid Efflux from CellsBiochemical and Biophysical Research Communications, 2002
- Paraoxonase 1 Overexpression in Mice and Its Effect on High-Density LipoproteinsBiochemical and Biophysical Research Communications, 2002
- Characterization of the ATPase Cycle of Human ABCA1: Implications for Its Function as a Regulator Rather Than an Active TransporterBiochemical and Biophysical Research Communications, 2001
- ATP-Binding Cassette Transporter-1 Induces Rearrangement of Actin Cytoskeletons Possibly through Cdc42/N-WASPBiochemical and Biophysical Research Communications, 2001
- Suppression of Endothelial Cell Apoptosis by High Density Lipoproteins (HDL) and HDL-associated LysosphingolipidsJournal of Biological Chemistry, 2001
- ABC1 Gene Expression and ApoA-I-Mediated Cholesterol Efflux Are Regulated by LXRBiochemical and Biophysical Research Communications, 2000
- Paraoxonase Activity Is Reduced by a Pro-atherosclerotic Diet in RabbitsBiochemical and Biophysical Research Communications, 2000
- Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient miceNature Genetics, 2000
- Reconstituted HDL Containing Human Apolipoprotein A-1 Reduces VCAM-1 Expression and Neointima Formation Following Periadventitial Cuff-Induced Carotid Injury in apoE Null MiceBiochemical and Biophysical Research Communications, 1999
- Mammalian Cdc42 Is a Brefeldin A-sensitive Component of the Golgi ApparatusJournal of Biological Chemistry, 1996