A central role for the endothelial NADPH oxidase in atherosclerosis
Open Access
- 20 April 2000
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 472 (1), 1-4
- https://doi.org/10.1016/s0014-5793(00)01397-1
Abstract
An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O2 − to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O2 −. We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.Keywords
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