Fetal cells in maternal blood of pregnancies with severe fetal growth restriction.
Open Access
- 1 January 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 15 (1), 218-221
- https://doi.org/10.1093/humrep/15.1.218
Abstract
The aim of this study was to examine whether, in pregnancies with severe early onset fetal growth restriction, the number of fetal erythroblasts in maternal blood is increased. The percentage of fetal erythroblasts in maternal blood, enriched by triple density gradient centrifugation and anti-CD71 magnetic cell sorting, was determined in 10 singleton pregnancies with severe intrauterine growth restriction in which there was Doppler ultrasound evidence of impaired placental perfusion. The values were compared to those of 10 normal pregnancies at the same gestational range of 22–26 weeks. In the growth restricted pregnancies the median number of fetal erythroblasts per 100 nucleated cells in maternal blood enriched for fetal cells was significantly higher than the median value in the control pregnancies (8.5% compared with 1%; P < 0.001). These data suggest that impaired uteroplacental perfusion and severe fetal growth restriction may be associated with placental damage leading to increased feto-maternal cell traffic. Alternatively the rate of transfer of fetal cells into the maternal circulation is not altered but in growth restriction the proportion of fetal erythroblasts in fetal blood is increased.Keywords
This publication has 15 references indexed in Scilit:
- Investigation of maternal blood enriched for fetal cells: Role in screening and diagnosis of fetal trisomiesAmerican Journal of Medical Genetics, 1999
- Abnormal levels of maternal serum human chorionic gonadotropin and alpha‐fetoprotein in the second trimester: Relation to fetal weight and preterm deliveryPrenatal Diagnosis, 1995
- The amniotic fluid index in normal human pregnancyAmerican Journal of Obstetrics and Gynecology, 1990
- Cordocentesis in the investigation of fetal erythropoiesisAmerican Journal of Obstetrics and Gynecology, 1989
- Measurement of human fetoplacental blood volume in erythroblastosis fetalisAmerican Journal of Obstetrics and Gynecology, 1987
- NEW DOPPLER TECHNIQUE FOR ASSESSING UTEROPLACENTAL BLOOD FLOWThe Lancet, 1983
- Alpha-Fetoprotein: A ReviewCRC Critical Reviews in Clinical Laboratory Sciences, 1981
- Serum alpha-fetoprotein in adults, in women during pregnancy, in children at birth, and during the first week of life: A sex differenceAmerican Journal of Obstetrics and Gynecology, 1977
- THE ULTRASTRUCTURE OF THE ARTERIAL SUPPLY OF THE HUMAN PLACENTA IN PREGNANCY COMPLICATED BY FETAL GROWTH RETARDATIONBJOG: An International Journal of Obstetrics and Gynaecology, 1976
- Hypoxemia and the Sudden Infant Death SyndromeScience, 1974