Mechanistical Analysis of Release Kinetics for Lipophilic Drug from Matrix-Type Drug Delivery Devices

Abstract

The release kinetics of lipophilic drug from hydrophobic polymer-based matrix-type drug delivery system was studied. Using the intrinsic formula, several experimental problems can be analyzed and solved. Intrinsic release, calculated from the model, evidently shows the true properties of the drug delivery system, which might have been disguised by the boundary layer effect. The results also demonstrated the need for maintaining sink condition and uniform distribution of dispersed phase in studying the matrix diffusion-controlled drug release.