Mononuclear cell infiltration in central portions of human astrocytomas
- 1 March 1988
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 68 (3), 432-437
- https://doi.org/10.3171/jns.1988.68.3.0432
Abstract
The mononuclear cell infiltration in the central portion of human low- and high-grade astrocytomas has been examined using monoclonal antibodies to cell surface differentiation antigens. There was no significant difference between the number of T cells, B cells, or macrophages. The OKT8+ (suppressor/cytotoxic) T cell population was the major lymphocyte subset in the infiltrates. There was, however, indirect evidence for a proportion of the total OKT8+ cells being natural killer cells. Overall, there was a significant difference in the number of macrophages compared to the total lymphoid cell population. Several cell types seem to play an equal role in the cellular and humoral immune response within the center of the tumors, as distinct from that occurring at the periphery.Keywords
This publication has 29 references indexed in Scilit:
- Relation between the site of primary intracranial tumors and mitogenic responses of blood lymphocytesCancer Immunology, Immunotherapy, 1986
- Normal values for the different classes of venous blood mononuclear cells defined by monoclonal antibodies.Journal of Clinical Pathology, 1985
- Regulation of Natural Killer Cell Function by Glass-adherent Cells in patients with Primary Intracranial MalignanciesNeurosurgery, 1984
- Lymphoid Cell-Glioma Cell Interaction Enhances Cell Coat Production by Human Gliomas: Novel Suppressor MechanismScience, 1983
- Biological and biochemical characterization of an interleukin 1‐like factor from rat C6 glioma cellsEuropean Journal of Immunology, 1983
- Membrane antigens of human cells of the monocyte/macrophage lineage studied with monoclonal antibodiesPathology, 1983
- Mechanisms by which human gliomas may escape cellular immune attackActa Neurochirurgica, 1982
- Impaired Immunocompetence in Patients with Malignant GliomasNeurosurgery, 1982
- Relationship of lymphocyte invasion and survival of brain tumor patientsAnnals of Neurology, 1978
- Lymphocytic infiltration in long-survival glioblastomas: Possible host's resistanceActa Neurochirurgica, 1977