Analysis of recombination in mammalian cells using SV4O genome segments having homologous overlapping termini
- 1 January 1980
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 8 (12), 2725-2736
- https://doi.org/10.1093/nar/8.12.2725
Abstract
Segments of SV40 DNA having homologous overlapping termini recombine to produce viable genomes in monkey cells. Frequencies of recombination on either side of a deletion marker are non-random; replication and palindromes do not appear to be essential. Since recombination involves host enzymes, a suitable system has been devised for analysing host cell recombination functions.Keywords
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