ERYTHROCYTE PRESERVATION. I. THE RELATION OF THE STORAGE LESION TO IN VIVO ERYTHROCYTE SENESCENCE 1

Abstract

During in vitro storage, characteristic changes occur in the fragility, glucose utilization, and the phosphorylated compounds associated with carbohydrate metabolism of the red cell. These alterations were not found during aging of the erythrocyte in vivo. in different species, storage damage was found to be similar and unrelated to the life span of the erythrocyte. The young erythrocyte was shown to be more susceptible to storage damage than the older cell. It was concluded that the changes of in vitro storage, referred to collectively as the storage lesion, bear no relationship to in vivo senescence of the erythrocyte.